Genomic manipulations defined at the nucleotide level have enabled various reverse engineering studies in Drosophila, providing new opportunities to study different biological functions. These genetic modifications include controlled removal, insertion and replacement of genetic fragments. Small fragments from a few bases to large fragments like megabase resolution can be manipulated to produce deletions, duplications, inversions, or translocations of chromosomes.
Drosophila has been an undoubtedly traditional model organism for a century, and its transgenesis is a labor-intensive process that requires optimized protocols and technical expertise. This process tends to divert attention from core research projects. The construction of stable, large-scale Drosophila mutants is fundamental to basic life and applied science research, and is an important medium for basic studies such as Cell Biology and Neuroscience, as well as preamble applications such as pest control and drug discovery. Learn more: Drosophila Transgenesis
